BACKGROUND:
Antioxidant vitamins are thought to play a role in atherosclerosis. Supplementation of these nutrients has been explored as a means of reducing cardiovascular morbidity and mortality.
PURPOSE:
To assess the evidence of the effectiveness of vitamin supplementation, specifically vitamins A, C, and E; beta-carotene; folic acid; antioxidant combinations; and multivitamin supplements, in preventing cardiovascular disease.
DATA SOURCES:
Cochrane Controlled Trials Registry and MEDLINE (1966 to September 2001), reference lists, and experts.