Osteoporosis - Mechanisms/Disease Processes

Specifics relating to the development of osteoporosis and disease mechanisms

The role of low acid load in vegetarian diet on bone health: a narrative review.

Vegetarian and vegan diets contain low amounts of protein and calcium. For this reason they are supposed to cause low bone mineral density (BMD) and osteoporosis. But this is not the case, except for vegans with a particularly low calcium intake. The absence of osteoporosis or low BMD can be explained by the low acid load of these diets. Nutritional acid load is negatively correlated with bone mineral density (BMD) and positively with fracture risk. Low acid load is correlated with lower bone resorption and higher BMD.

A moderately low phosphate intake may provide health benefits analogous to those conferred by UV light - a further advantage of vegan diets.

Although exposure to ultraviolet light is often viewed as pathogenic owing to its role in the genesis of skin cancer and skin aging, there is growing epidemiological evidence that such exposure may decrease risk for a number of more serious cancers, may have a favorable impact on blood pressure and vascular health, and may help to prevent certain autoimmune disorders - in addition to its well-known influence on bone density. Most likely, these health benefits are reflective of improved vitamin D status.

Low levels of osteocalcin and leptin in serum of vegetarian prepubertal children.

BACKGROUND:Scientific literature points to the positive association between vegetarian diet and reduced risk for cardiovascular diseases, some types of cancer and diabetes. On the other hand elimination of animal products from the diet decreases the intake of some essential nutrients which may influence bone metabolism. This is a very important problem especially in childhood and adolescence, when growth and bone turnover are the most intensive. Bone metabolism is regulated by variety factors, which are involved in the bone formation and bone resorption processes.

Calcaneum broadband ultrasound attenuation relates to vegetarian and omnivorous diets differently in men and women: an observation from the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population study.

Vegetarian diets have been suggested to be beneficial for bone health due to increased consumption of plant foods, including soya, or reduced consumption of meat. However, meat may also be beneficial for bone health. The evidence relating diet to bone health is based largely on studies of women, often in those at high risk of osteoporosis. Few studies have investigated dietary inter-relationships in men as well as women from general populations.

Serum concentration of biochemical bone turnover markers in vegetarian children.

PURPOSE: In general, most children on well-planned vegetarian diets can achieve normal growth and development. However, elimination of animal products from the diet decreases the intake of some essential nutrients, such as calcium and vitamin D, and may influence bone metabolism. This is especially important in childhood and adolescence, when growth and bone turnover are most intensive. The aim of this study was to investigate the serum concentrations of biochemical bone turnover markers in prepubertal vegetarian children.

Consequences of a plant-based diet with low dairy consumption on intake of bone-relevant nutrients.

OBJECTIVE:This study examines the extent to which a plant-based dietary intervention that discourages consumption of dairy products and meat influences bone-relevant nutrients. METHODS:A randomized controlled study design was used to evaluate the Coronary Health Improvement Project. The Project is a heart disease prevention intervention administered in an intensive 40-hour educational course delivered over a 4-week period. Participants were evaluated at baseline, 6 weeks, and 6 months.

[Effect of vitamin D supplementation on serum 25-hydroxyvitamin D and bone turnover markers concentrations in vegetarian children].

PURPOSE:Vitamin D plays a key role in bone mineralization by regulating calcium and phosphate metabolism. Deficiency of this vitamin may lead to disturbances in bone metabolism as well as to osteopenia and osteoporosis. AIM:1. Assessment of daily intake of calcium and vitamin D in children on vegetarian diet. 2. Measurement of serum 25-hydroxyvitamin D and biochemical bone turnover markers levels in vegetarian children supplemented with calcium and vitamin D, before and after the intervention.

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