High-carbohydrate, high-fiber diets for insulin-treated men with diabetes mellitus.

The effects of high-carbohydrate, high plant fiber (HCF) diets on glucose and lipid metabolism of 20 lean men receiving insulin therapy for diabetes mellitus were evaluated on a metabolic ward. All men received control diets for an average of 7 days followed by HCF diets for an average of 16 days. Diets were designed to be weight-maintaining and there were no significant alterations in body weight. The daily dose of insulin was lower for each patient on the HCF diet than on the control diet.

Low-fat diet and therapeutic doses of insulin in diabetes mellitus.

THERE is no indication that healthy people taking a diet rich in carbohydrates are especially liable to diabetes ; in fact numerous observations show improvement of carbohydrate tolerance following its greater intake. The Staub-Traugott effect is a classical example of this in acute experiments. As a long-term effect diabetes mellitus is not especially common among the huge and mainly carbohydrate-eating populations of the world-e.g., the Chinese-except the rich and the sedentary among them who partake of large quantities of fat as well and encourage obesity by overeating.

Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population

Mice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we examined links between protein intake and mortality. Respondents aged 50–65 reporting high protein intake had a 75% increase in overall mortality and a 4-fold increase in cancer death risk during the following 18 years. These associations were either abolished or attenuated if the proteins were plant derived.

Alcohol consumption and risk of coronary heart disease among men with type 2 diabetes mellitus.

The goal of this study was to examine the relationship between alcohol intake and risk of coronary heart disease (CHD) among men with type 2 diabetes.

Type 2 diabetes is associated with an increased risk of CHD. Emerging evidence suggests that moderate alcohol intake is associated with an important reduction in risk of CHD in individuals with type 2 diabetes.

Environmental factors in the etiology of type 1 diabetes.

Type 1 diabetes is considered to be an autoimmune disease in which T lymphocytes infiltrate the islets of pancreas and destroy the insulin producing beta cell population. Besides antigen specificity, the quality of immune reactivity against islet cell antigen(s) is an important determinant of the beta cell destruction. Much evidence indicates that the function of the gut immune system is central in the pathogenesis, as the regulation of the gut immune system may be aberrant in type 1 diabetes.


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